[转移性结直肠癌根治性肝切除术后预防性肝动脉灌注化疗的评估]
[Evaluation of prophylactic hepatic arterial infusion chemotherapy after curative hepatectomy for metastatic colorectal cancer].
作者信息
Tokuoka Masayoshi, Kashiwazaki Masaki, Takeda Yutaka, Hasuike Yasunori, Mishima Hideyuki, Ikenaga Masakazu, Masuda Norikazu, Hirao Motohiro, Fujitani Kazumasa, Sawamura Toshiro, Tsujinaka Toshimasa
机构信息
Dept. of Surgery, National Hospital Organization Osaka National Hospital.
出版信息
Gan To Kagaku Ryoho. 2004 Oct;31(11):1806-8.
We evaluated the effect of hepatic arterial infusion (HAI) chemotherapy after curative resection of liver metastases of colorectal cancer. A total of 161 patients underwent curative resection of liver metastases. Among them, 50 patients underwent HAI of 5-FU, and 111 patients had no HAI therapy. The 50% disease-free survival time (50% DFS) was 758 days and 342 days in the HAI group and the non-HAI group (logrank test, p<0.01), and the 50% overall survival time (50% OS) was 978 days versus 730 days (p<0.05), respectively. Among the 71 patients with multiple resectable metastases (H2 or H3), the HAI group had a significantly superior 50% DFS. HAI therapy seems to be an effective form of adjuvant chemotherapy after hepatic resection of metastatic colorectal cancer.
我们评估了肝动脉灌注（HAI）化疗对结直肠癌肝转移灶根治性切除术后的疗效。共有161例患者接受了结直肠癌肝转移灶的根治性切除。其中，50例患者接受了5-氟尿嘧啶的肝动脉灌注治疗，111例患者未接受肝动脉灌注治疗。肝动脉灌注组和非肝动脉灌注组的50%无病生存时间（50% DFS）分别为758天和342天（对数秩检验，p<0.01），50%总生存时间（50% OS）分别为978天和730天（p<0.05）。在71例有多个可切除转移灶（H2或H3）的患者中，肝动脉灌注组的50% DFS明显更优。肝动脉灌注治疗似乎是转移性结直肠癌肝切除术后一种有效的辅助化疗方式。
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