Boiten J, Algra A, Moll F L, van de Pavoordt H D W M, Kappelle L J
St. Jans Gasthuis, afd. Neurologie, Weert.
Ned Tijdschr Geneeskd. 2004 Oct 9;148(41):2009-12.
Carotid endarterectomy (CE) is of proven value for patients with a high-grade symptomatic stenosis of the internal carotid artery (ICA). Recently, the Asymptomatic Carotid Atherosclerosis Study group showed that in patients with an asymptomatic ICA stenosis of more than 60%, CE caused an absolute risk reduction of perioperative death or stroke during 5 year follow-up of 5.4% (95% confidence interval: 3.0-7.8). Half of these strokes were disabling. The number needed to treat to save one patient from death within 30 days or stroke within in the following 5 years was 19. Further studies are needed to isolate a group of patients that will substantially benefit from the operation. CE is probably most effective in males under 75 years of age. A low surgical morbidity and mortality is an absolute prerequisite to justify CE for an asymptomatic ICA stenosis.
对于有症状的颈内动脉(ICA)高度狭窄患者,颈动脉内膜切除术(CE)已被证明具有价值。最近,无症状颈动脉粥样硬化研究组表明,在无症状ICA狭窄超过60%的患者中,CE在5年随访期间使围手术期死亡或卒中的绝对风险降低了5.4%(95%置信区间:3.0 - 7.8)。这些卒中中有一半导致残疾。为使一名患者在30天内免于死亡或在接下来5年内免于卒中而需要治疗的患者数量为19名。需要进一步研究以确定一组将从该手术中显著获益的患者。CE可能对75岁以下男性最有效。低手术发病率和死亡率是对无症状ICA狭窄进行CE治疗的绝对前提条件。