实验性变应性脑脊髓炎中的诱发电位：一项关于可控疾病病程中诱发电位变化的研究。

Evoked potentials (EPs) in experimental allergic encephalomyelitis: a study of EP modifications during the course of a controlled disease.

作者信息

Onofrj M, Gambi D, Bazzano S, Colamartino P, Fulgente T, Malatesta G, Ferracci F

机构信息

Department of Neurology, Università Statale G. D'Annunzio, Facoltà di Medicina e Chirurgia, Chieti, Italy.

出版信息

Electromyogr Clin Neurophysiol. 1992 Mar;32(3):125-35.

PMID:1555527

Abstract

24 juvenile strain 13 guinea pigs were sensitized with homologous spinal cord homogenate in complete Freund's adjuvant in order to obtain Experimental Allergic Encephalomyelitis (EAE) in the Chronic Relapsing (CR-EAE), Chronic Progressive (CP-EAE) and Acute (A-EAE) forms. Visual, Brain-Stem Acoustic, Somatosensory Evoked Potentials were recorded in these animals, prior to the sensitizing injection and during the course of the disease. The aim of our study was to observe modifications of Evoked Potentials during progression of a demyelinating disease. Latency delays of Evoked Potentials appeared 15 days after the sensitizing injection, preceding or simultaneously with clinical alterations and when demyelinated plaques were not detected in anatomical specimens.

摘要

24只幼年13号品系豚鼠用同源脊髓匀浆与完全弗氏佐剂致敏，以获得慢性复发性（CR-EAE）、慢性进行性（CP-EAE）和急性（A-EAE）形式的实验性变应性脑脊髓炎（EAE）。在致敏注射前和疾病过程中，对这些动物记录视觉、脑干听觉、体感诱发电位。我们研究的目的是观察脱髓鞘疾病进展过程中诱发电位的变化。诱发电位潜伏期延迟在致敏注射后15天出现，先于或与临床改变同时出现，且在解剖标本中未检测到脱髓鞘斑块时出现。