泰利霉素对侵袭性感染成年患者中对红霉素敏感及耐药的肺炎链球菌分离株的活性。
Activity of telithromycin against erythromycin-susceptible and -resistant Streptococcus pneumoniae isolates from adults with invasive infections.
作者信息
Ortega Mar, Marco Francesc, Almela Manel, Puig Jorge, Soriano Alex, Mensa Josep
机构信息
Infectious Diseases Unit, Hospital Clínic, Barcelona, Spain.
出版信息
Int J Antimicrob Agents. 2004 Dec;24(6):616-8. doi: 10.1016/j.ijantimicag.2004.06.018.
A telithromycin (TEL) kill-kinetics study was conducted with 120 clinically significant Streptococcus pneumoniae isolates (60 susceptible and 60 highly resistant to erythromycin). Time-kill curves were performed using different antibiotic concentrations. The minimum inhibitory concentrations (MICs) of TEL were low for both erythromycin-susceptible (MIC < or = 0.016 mg/L) and erythromycin-resistant strains (MIC < or = 0.25 mg/L). TEL showed 99.9% killing of all erythromycin resistant strains at 18-24 h of incubation. Even for strains with erythromycin MICs > or = 64.0 mg/L, TEL was uniformly bactericidal at 0.25 mg/L.
对120株具有临床意义的肺炎链球菌分离株（60株对红霉素敏感，60株对红霉素高度耐药）进行了泰利霉素（TEL）杀菌动力学研究。使用不同抗生素浓度绘制时间-杀菌曲线。泰利霉素对红霉素敏感菌株（MIC≤0.016mg/L）和红霉素耐药菌株（MIC≤0.25mg/L）的最低抑菌浓度（MIC）均较低。在培养18 - 24小时时，泰利霉素对所有红霉素耐药菌株显示出99.9%的杀菌率。即使对于红霉素MIC≥64.0mg/L的菌株，泰利霉素在0.25mg/L时仍具有一致的杀菌作用。
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