细胞外基质成分WIF-1在视网膜发育过程中表达，并可对其进行调节。
The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development.
作者信息
Hunter Dale D, Zhang Minlei, Ferguson Jill W, Koch Manuel, Brunken William J
机构信息
Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
出版信息
Mol Cell Neurosci. 2004 Dec;27(4):477-88. doi: 10.1016/j.mcn.2004.08.003.
We have shown previously that components of the extracellular matrix (ECM) modulate neuronal development. Here, we searched for additional ECM elements that might play roles in retinal histogenesis and identified a secreted glycoprotein that is heavily expressed in the retina. This molecule, named by others Wnt Inhibitory Factor-1 (WIF-1), is expressed during and after the period of rod photoreceptor morphogenesis in the mouse. We show that a potential WIF-1 ligand, Wnt4, as well as a potential Wnt4 receptor, fzd4, and a potential Wnt4 coreceptor, LRP6, are expressed in the region of, and at the time of, rod photoreceptor genesis. WIF-1 and Wnt4 are coexpressed during retinal development and bind to each other; therefore, they are likely to interact during rod production. WIF-1 protein inhibits rod production, and anti-WIF-1 antibodies increase rod production; in contrast, Wnt4 promotes rod production. Together, these data suggest that WIF-1 and Wnt4, both components of the ECM, regulate mammalian photoreceptor development.
我们之前已经表明，细胞外基质（ECM）的成分可调节神经元发育。在此，我们寻找可能在视网膜组织发生中起作用的其他ECM成分，并鉴定出一种在视网膜中大量表达的分泌型糖蛋白。这种分子，被其他人命名为Wnt抑制因子-1（WIF-1），在小鼠视杆光感受器形态发生期间及之后表达。我们发现一种潜在的WIF-1配体Wnt4，以及一种潜在的Wnt4受体fzd4和一种潜在的Wnt4共受体LRP6，在视杆光感受器发生的区域和时间表达。WIF-1和Wnt4在视网膜发育过程中共同表达并相互结合；因此，它们可能在视杆细胞产生过程中相互作用。WIF-1蛋白抑制视杆细胞的产生，而抗WIF-1抗体则增加视杆细胞的产生；相反，Wnt4促进视杆细胞的产生。这些数据共同表明，作为ECM成分的WIF-1和Wnt4调节哺乳动物光感受器的发育。
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