Isaac John T R, Mellor Jack, Hurtado David, Roche Katherine W
National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3701, USA.
Pharmacol Ther. 2004 Dec;104(3):163-72. doi: 10.1016/j.pharmthera.2004.08.006.
Recently, there has been intense interest in the mechanisms regulating the trafficking and synaptic targeting of kainate receptors in neurons. This topic is still in its infancy when compared with studies of trafficking of other ionotropic glutamate receptors; however, it is already clear that mechanisms exist for subunit- and splice variant-specific trafficking of kainate receptors. There is also enormous diversity of kainate receptor targeting, with the best-studied neurons in this regard being hippocampal CA3 pyramidal neurons and CA1 GABAergic interneurons. This review summarizes the current state of knowledge on this topic, focusing on the molecular mechanisms of kainate receptor trafficking and the potential for these mechanisms to regulate neuronal kainate receptor function.
最近，人们对调节神经元中红藻氨酸受体的运输和突触靶向的机制产生了浓厚兴趣。与其他离子型谷氨酸受体的运输研究相比，这个主题仍处于起步阶段；然而，已经清楚的是，存在针对红藻氨酸受体亚基和剪接变体特异性运输的机制。红藻氨酸受体的靶向也具有极大的多样性，在这方面研究得最透彻的神经元是海马CA3锥体神经元和CA1 GABA能中间神经元。本综述总结了该主题的当前知识状态，重点关注红藻氨酸受体运输的分子机制以及这些机制调节神经元红藻氨酸受体功能的潜力。
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