Mosler P, Mergener K, Denzer U, Kiesslich R, Galle P R, Kanzler S
I. Medizinische Klinik und Poliklinik der Johannes-Gutenberg-Universität Mainz, Germany.
Z Gastroenterol. 2004 Nov;42(11):1289-93. doi: 10.1055/s-2004-813586.
Anticoagulants and antiplatelet agents are widely used in the prophylaxis and management of thromboembolic and cardiovascular diseases. Gastrointestinal bleeding is a well-known complication of these agents. Modification of anticoagulant and antiplatelet therapy is often required in patients undergoing surgical procedures and specific recommendations for the perioperative period have been issued. Fewer data exist with regard to the use of these agents around the time of endoscopic procedures. A survey of the American Society for Gastrointestinal Endoscopy (ASGE), performed several years ago, showed a wide variation between endoscopists in the management of anticoagulants and antiplatelet agents in the periendoscopic period. Subsequently, guidelines have been proposed by the ASGE as well as the German Society for Gastroenterology (DGVS). The aim of this study was to investigate the current practices among German endoscopists regarding the use of these medications in patients undergoing endoscopic procedures and to assess their adherence to published guidelines. Our data demonstrate that, in spite of the dissemination of guidelines, there is still a wide variation in the periendoscopic management of patients who are at increased risk for bleeding due to anticoagulants, especially in patients taking antiplatelet agents.
抗凝剂和抗血小板药物广泛用于血栓栓塞性疾病和心血管疾病的预防及治疗。胃肠道出血是这些药物众所周知的并发症。接受外科手术的患者通常需要调整抗凝和抗血小板治疗,并且已经发布了围手术期的具体建议。关于在内镜检查期间使用这些药物的数据较少。几年前美国胃肠内镜学会(ASGE)进行的一项调查显示,内镜医师在围内镜期对抗凝剂和抗血小板药物的管理存在很大差异。随后,ASGE以及德国胃肠病学会(DGVS)都提出了指南。本研究的目的是调查德国内镜医师在接受内镜检查的患者中使用这些药物的当前做法,并评估他们对已发表指南的遵守情况。我们的数据表明,尽管指南已经发布,但在因抗凝剂而出血风险增加的患者的围内镜管理中,仍然存在很大差异,尤其是在服用抗血小板药物的患者中。