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冠状动脉旁路移植术(CABG)患者升主动脉粥样硬化存在的相关因素。

Factors associated with presence of ascending aortic atherosclerosis in CABG patients.

作者信息

Schachner Thomas, Nagele Georg, Kacani Andre, Laufer Günther, Bonatti Johannes

机构信息

Department of Cardiac Surgery, Innsbruck University Hospital, Innsbruck, Austria.

出版信息

Ann Thorac Surg. 2004 Dec;78(6):2028-32; discussion 2032. doi: 10.1016/j.athoracsur.2004.04.078.

Abstract

BACKGROUND

The indication for epiaortic scanning during coronary artery operation is still a matter of debate. Whether this test should be carried out selectively or on a routine basis is unclear. The aim of this study was to determine factors that predict the presence of atherosclerotic ascending aortic wall thickening in patients undergoing coronary artery bypass grafting (CABG).

METHODS

A total of 500 CABG patients underwent epiaortic scanning using a high-frequency linear ultrasonic probe. Maximum ascending aortic wall thickness was measured and correlated with patient-related variables.

RESULTS

Maximum ascending aortic wall thickness significantly correlated with age (p < 0.001), preoperative creatinine level (p = 0.004), European system for cardiac operative risk evaluation (EuroSCORE, p < 0.001), and maximum descending aortic wall thickness (p < 0.001). Body mass index and left ventricular ejection fraction showed no correlation with maximum ascending aortic wall thickness. Of the categorical variables, hypertension (p = 0.02), unstable angina (p = 0.04), chronic obstructive pulmonary disease (p = 0.02), cerebrovascular disease (p < 0.001), and peripheral vascular disease (p < 0.001) were associated with increased ascending aortic wall thickness whereas sex, diabetes, acute cases, and previous cardiac operation were not. Multivariate analysis revealed maximum descending aortic wall thickness (p < 0.001), cerebrovascular disease (p = 0.03), and peripheral vascular disease (p = 0.04) as independent variables significantly associated with maximum ascending aortic wall thickness.

CONCLUSIONS

If epiaortic scanning is not carried out routinely for detection of ascending aortic arteriosclerosis it should at least be performed in patients with old age, hypertension, unstable angina, chronic obstructive pulmonary disease, cerebrovascular disease, peripheral vascular disease, elevated creatinine levels, higher EuroSCOREs, and increased wall thickness of the descending aorta.

摘要

背景

冠状动脉手术期间进行主动脉弓扫描的指征仍存在争议。该检查是应选择性进行还是常规进行尚不清楚。本研究的目的是确定预测冠状动脉旁路移植术(CABG)患者存在动脉粥样硬化性升主动脉壁增厚的因素。

方法

共有500例CABG患者使用高频线性超声探头进行了主动脉弓扫描。测量升主动脉壁最大厚度并与患者相关变量进行关联分析。

结果

升主动脉壁最大厚度与年龄(p < 0.001)、术前肌酐水平(p = 0.004)、欧洲心脏手术风险评估系统(EuroSCORE,p < 0.001)以及降主动脉壁最大厚度(p < 0.001)显著相关。体重指数和左心室射血分数与升主动脉壁最大厚度无相关性。在分类变量中,高血压(p = 0.02)、不稳定型心绞痛(p = 0.04)、慢性阻塞性肺疾病(p = 0.02)、脑血管疾病(p < 0.001)和外周血管疾病(p < 0.001)与升主动脉壁厚度增加相关,而性别、糖尿病、急症病例和既往心脏手术则无此关联。多变量分析显示,降主动脉壁最大厚度(p < 0.001)、脑血管疾病(p = 0.03)和外周血管疾病(p = 0.04)是与升主动脉壁最大厚度显著相关的独立变量。

结论

如果不常规进行主动脉弓扫描以检测升主动脉动脉硬化,那么至少应对老年、高血压、不稳定型心绞痛、慢性阻塞性肺疾病、脑血管疾病、外周血管疾病、肌酐水平升高、EuroSCORE较高以及降主动脉壁厚度增加的患者进行该项检查。

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