补充组氨酸可抑制大鼠的食物摄入量和脂肪堆积。
Histidine supplementation suppresses food intake and fat accumulation in rats.
作者信息
Kasaoka Seiichi, Tsuboyama-Kasaoka Nobuyo, Kawahara Yumi, Inoue Setsuko, Tsuji Makiko, Ezaki Osamu, Kato Hideo, Tsuchiya Takahide, Okuda Hiromichi, Nakajima Shigeru
机构信息
Department of Health and Nutrition, Bunkyo University Women's College, Kanagawa, Japan.
出版信息
Nutrition. 2004 Nov-Dec;20(11-12):991-6. doi: 10.1016/j.nut.2004.08.006.
OBJECTIVE
Histamine, a derivative of histidine, decreases food intake and body fat by activation of histamine neurons. Our objective was to clarify the effect of dietary histidine, in particular, on food intake and/or body fat accumulation in rats.
METHODS
Male Wistar rats were assigned to one of four groups after acclimation and allowed free access to diets containing 20% casein (0% histidine), 20% casein plus 1.0% histidine, 20% casein plus 2.5% histidine, or 20% casein plus 5% histidine for 8 d.
RESULTS
Food intake and body weight were recorded daily and compared between groups. During the experimental period, food intake decreased according to the increases in dietary histidine. There was a negative and significant (P < 0.01) correlation between dietary histidine (grams per 8 d) and retroperitoneal fat pad (grams per 100 g of body weight). Uncoupling protein-1 mRNA in brown adipose tissue increased with increases in dietary histidine.
CONCLUSION
Our results indicate that dietary histidine suppresses food intake and fat accumulation in rats.
目的
组胺是组氨酸的衍生物，通过激活组胺神经元来减少食物摄入量和体脂。我们的目的是阐明膳食组氨酸，特别是对大鼠食物摄入量和/或体脂积累的影响。
方法
雄性Wistar大鼠适应环境后被分为四组之一，允许其自由进食含20%酪蛋白（0%组氨酸）、20%酪蛋白加1.0%组氨酸、20%酪蛋白加2.5%组氨酸或20%酪蛋白加5%组氨酸的日粮，持续8天。
结果
每天记录食物摄入量和体重，并在组间进行比较。在实验期间，食物摄入量随着日粮组氨酸含量的增加而减少。日粮组氨酸（每8天克数）与腹膜后脂肪垫（每100克体重克数）之间存在负相关且具有显著性（P < 0.01）。棕色脂肪组织中的解偶联蛋白-1 mRNA随着日粮组氨酸含量的增加而增加。
结论
我们的结果表明，膳食组氨酸可抑制大鼠的食物摄入量和脂肪积累。
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