Chakkera Harini A, O'Hare Ann M, Johansen Kirsten L, Hynes Denise, Stroupe Kevin, Colin Philip M, Chertow Glenn M
Department of Medicine, Division of Nephrology,University of California, San Francisco, California, 94143-0532, USA.
J Am Soc Nephrol. 2005 Jan;16(1):269-77. doi: 10.1681/ASN.2004040333. Epub 2004 Nov 24.
Inferior outcomes after kidney transplantation among African Americans are poorly understood. It was hypothesized that unequal access to medical care among transplant recipients might contribute to worse posttransplantation outcomes among African Americans and that racial disparities in kidney transplant outcomes would be less pronounced among patients who receive health care within versus outside the Department of Veterans Affairs (VA), because eligible veterans who receive care within the VA are entitled to receive universal access to care, including coverage of prescription drugs. A study cohort of 79,361 patients who were undergoing their first kidney transplant in the United States between October 1, 1991, and October 31, 2000, was assembled, with follow-up data on graft survival obtained through October 31, 2001. After multivariable proportional hazards adjustment for a wide range of recipient and donor characteristics, African-American patients were at increased risk for graft failure compared with non-African-American patients (relative risk [RR] 1.31; 95% confidence interval [CI] 1.26 to 1.36). African-American race was associated with a similarly increased risk for graft failure among patients who were VA users (RR 1.31; 95% CI 1.11 to 1.54) and non-VA users (RR 1.31; 95% CI 1.26 to 1.36). In conclusion, racial disparities in kidney transplant outcomes seem to persist even in a universal access-to-care system such as the VA. Reasons for worse outcomes among African Americans require further investigation.
非洲裔美国人肾移植后预后较差的情况尚未得到充分了解。据推测,移植受者获得医疗服务的机会不平等可能导致非洲裔美国人移植后预后更差,而且在退伍军人事务部(VA)内部接受医疗服务的患者与在VA外部接受医疗服务的患者相比,肾移植结果中的种族差异可能不那么明显,因为在VA内部接受治疗的符合条件的退伍军人有权获得全面的医疗服务,包括处方药保险。研究人员组建了一个队列,纳入了1991年10月1日至2000年10月31日期间在美国接受首次肾移植的79361名患者,并获取了截至2001年10月31日的移植物存活随访数据。在对广泛的受者和供者特征进行多变量比例风险调整后,与非非洲裔美国患者相比,非洲裔美国患者移植物失败的风险增加(相对风险[RR]为1.31;95%置信区间[CI]为1.26至1.36)。在VA使用者(RR为1.31;95%CI为1.11至1.54)和非VA使用者(RR为1.31;95%CI为1.26至1.36)中,非洲裔种族与移植物失败风险的增加情况相似。总之,即使在像VA这样的全面医疗服务体系中,肾移植结果中的种族差异似乎仍然存在。非洲裔美国人预后较差的原因需要进一步调查。