Jones Ronald W, Sadler Lynn, Grant Steven, Whineray Janet, Exeter Melissa, Rowan Darion
Department of Gynecological Oncology, National Women's Hospital, Auckland, New Zealand.
J Reprod Med. 2004 Oct;49(10):808-11.
To identify clinical factors that might identify women with vulvar lichen sclerosus who are at increased risk of developing squamous cell cacinoma.
A retrospective, case-control study compared 46 women presenting between 1992 and 2000 with clinical and histologic evidence of squamous cell carcinoma of the vulva arising in a background of lichen sclerosus and 213 new referrals with vulvar lichen sclerosus during the same period.
The ages of the patients and presence of clinical hyperplasia were the only differences between the 2 groups.
Women presenting with vulvar cancer arising within a background of lichen sclerosus are significantly older than women presenting with lichen sclerosus. In addition, clinical evidence of squamous hyperplasia is independently associated with vulvar carcinoma. Neither the presence nor duration of symptoms nor the loss of vulvar architecture is a useful indicator of potential cancer risk.
确定可能识别出患鳞状细胞癌风险增加的外阴硬化性苔藓女性的临床因素。
一项回顾性病例对照研究，比较了1992年至2000年间出现的46例有临床和组织学证据表明在硬化性苔藓背景下发生外阴鳞状细胞癌的女性，以及同期213例新转诊的外阴硬化性苔藓患者。
两组之间唯一的差异是患者年龄和临床增生的存在情况。
在硬化性苔藓背景下出现外阴癌的女性明显比患硬化性苔藓的女性年龄大。此外，鳞状上皮增生的临床证据与外阴癌独立相关。症状的存在与否、持续时间以及外阴结构的丧失都不是潜在癌症风险的有用指标。
