Chez Michael G, Memon Shoaib, Hung Paul C
Department of Neurology, The Chicago Medical School, North Chicago, IL, USA.
Semin Pediatr Neurol. 2004 Sep;11(3):229-35. doi: 10.1016/j.spen.2004.07.007.
Child neurologists are likely to be caring for an increasing number of patients with autistic spectrum disorder (ASD). ASD may occur in as many as 1/100 to 1/200 births. It appears to be a multifactorial disease, with many phenotypes or subgroups. No simple treatment is currently approved for curing or managing core symptoms of autism. We rationally propose a symptom-based review of what treatments may offer relief to specific subtypes of clinical behaviors seen in autism. There is a lack of clinically based evidence on which to universally recommend a rational clinical algorithm for treatment; we suggest that rational pharmacotherapy may offer symptomatic relief to core areas of dysfunction in the autistic population. Future research into rational medical treatment options is desperately needed.
儿童神经科医生可能会照料越来越多的自闭症谱系障碍（ASD）患者。ASD的发病率可能高达1/100至1/200出生人口。它似乎是一种多因素疾病，具有多种表型或亚组。目前尚无经批准的简单疗法可治愈或管理自闭症的核心症状。我们合理地建议基于症状来审视哪些治疗方法可能缓解自闭症中特定临床行为亚型的症状。缺乏基于临床的证据来普遍推荐合理的临床治疗算法；我们认为合理的药物治疗可能会缓解自闭症人群功能障碍的核心领域的症状。迫切需要对合理的医学治疗选择进行进一步研究。
