[蛋白聚糖基因敲除小鼠与骨关节炎]
[Proteoglycan knock-out mice and osteoarthritis].
作者信息
Shinomura Tamayuki
机构信息
Tissue Regeneration, Department of Hard Tissue Engineering, Tokyo Medical and Dental University.
出版信息
Clin Calcium. 2004 Jul;14(7):58-63.
PMID:15577077
Abstract
There are several types of small leucine-rich proteoglycans expressed in articular cartilage and its surrounding tissues. Many of these proteoglycans are functioning as a modulator of collagen fibrillogenesis via binding to the surface of collagen fibers. Therefore, deficiencies of their expression in knock-out mice often result in the formation of abnormal collagen fibers leading to the instability of the join, and finally trigger osteoarthritis.
摘要
在关节软骨及其周围组织中表达有几种富含亮氨酸的小分子蛋白聚糖。这些蛋白聚糖中的许多通过与胶原纤维表面结合，发挥着胶原纤维形成调节因子的作用。因此，基因敲除小鼠中这些蛋白聚糖表达的缺陷常常导致异常胶原纤维的形成，进而导致关节不稳定，最终引发骨关节炎。
相似文献
1
[Proteoglycan knock-out mice and osteoarthritis].
Clin Calcium. 2004 Jul;14(7):58-63.
2
The role of small leucine-rich proteoglycans in collagen fibrillogenesis.
Matrix Biol. 2010 May;29(4):248-53. doi: 10.1016/j.matbio.2010.01.001. Epub 2010 Jan 18.
3
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.
Arthritis Res Ther. 2005;7(4):R852-61. doi: 10.1186/ar1756. Epub 2005 May 12.
4
The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules.
Bioessays. 1995 Dec;17(12):1039-48. doi: 10.1002/bies.950171208.
5
Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction.
Arthritis Res Ther. 2006;8(6):R158. doi: 10.1186/ar2053.
6
Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice.
Arthritis Rheum. 2009 Aug;60(8):2362-71. doi: 10.1002/art.24705.
7
[Structure and regulation of articular cartilage proteoglycan expression].
Pathol Biol (Paris). 2001 May;49(4):364-75. doi: 10.1016/s0369-8114(01)00145-6.
8
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis.
FEBS J. 2007 Aug;274(16):4246-55. doi: 10.1111/j.1742-4658.2007.05951.x. Epub 2007 Jul 25.
9
A role for decorin in the remodeling of myocardial infarction.
Matrix Biol. 2005 Jun;24(4):313-24. doi: 10.1016/j.matbio.2005.05.003.
10
Syndecan-1 expression is upregulated in degenerating articular cartilage in a transgenic mouse model for osteoarthritis.
Scand J Rheumatol. 2005 Nov-Dec;34(6):469-74. doi: 10.1080/03009740500304338.
Zotero 插件