Okada Natsuko
Department of Dermatology, Osaka Kosei-nenkin Hospital.
Clin Calcium. 2004 Oct;14(10):145-9.
Steroid-induced osteoporosis is the most common form of osteoporosis in the dermatological diseases, but there have been only few data concerning the treatment based on clinical evidences. For management of osteoporosis, the efficacy of vitamin D(3) and bisphosphonate had been demonstrated by meta-analytic approach. Ten dermatological patients in our clinic who had received long-term oral steroids and showed bone loss were treated with 5 mg/day of alendronate for one year, and showed significant increase in the bone mineral density of the lumbar spine. In dermatological patients requiring long-term systemic steroids, administration of drugs such as vitamin D(3) or bisphosphonate should be started earlier.
类固醇诱导的骨质疏松症是皮肤病中最常见的骨质疏松症形式,但基于临床证据的治疗数据很少。对于骨质疏松症的管理,维生素D(3)和双膦酸盐的疗效已通过荟萃分析方法得到证实。我们诊所的10名接受长期口服类固醇并出现骨质流失的皮肤病患者,每天服用5毫克阿仑膦酸钠治疗一年,腰椎骨密度显著增加。对于需要长期全身性类固醇治疗的皮肤病患者,应更早开始使用维生素D(3)或双膦酸盐等药物。