嗜铬细胞瘤患者棕色脂肪组织的放射性核素成像代谢活性。
Radionuclide imaging metabolic activity of brown adipose tissue in a patient with pheochromocytoma.
作者信息
Fukuchi K, Tatsumi M, Ishida Y, Oku N, Hatazawa J, Wahl R L
机构信息
Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan.
出版信息
Exp Clin Endocrinol Diabetes. 2004 Nov;112(10):601-3. doi: 10.1055/s-2004-830407.
We describe a patient with extra-adrenal pheochromocytoma and high plasma norepinephrine levels. Radionuclide images of this patient obtained using (18)F-fluorodeoxyglucose and (123)I-metaiodobenzylguanidine revealed bilateral tracer accumulation in the shoulder and lower neck. The regions of radiotracer uptake corresponded to the location of human brown adipose tissue (BAT). Excessive sympathetic stimulation by high circulating catecholamine concentrations augmented the metabolic activity and tracer uptake in the BAT. This study showed that radionuclide imaging can noninvasively visualize human BAT in terms of metabolic and functional activity.
我们描述了一名患有肾上腺外嗜铬细胞瘤且血浆去甲肾上腺素水平较高的患者。使用（18）F - 氟脱氧葡萄糖和（123）I - 间碘苄胍获得的该患者的放射性核素图像显示，双侧示踪剂在肩部和下颈部积聚。放射性示踪剂摄取区域与人类棕色脂肪组织（BAT）的位置相对应。高循环儿茶酚胺浓度引起的过度交感神经刺激增强了BAT中的代谢活性和示踪剂摄取。这项研究表明，放射性核素成像可以从代谢和功能活动方面无创地可视化人类BAT。
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