针对Nef与宿主细胞蛋白之间相互作用的治疗靶向

Therapeutic targeting of interactions between Nef and host cell proteins.

作者信息

Saksela Kalle

机构信息

Institute of Medical Technology and Tampere University Hospital, University of Tampere, FIN-33014, Finland.

出版信息

Curr Drug Targets Immune Endocr Metabol Disord. 2004 Dec;4(4):315-9. doi: 10.2174/1568008043339776.

DOI:10.2174/1568008043339776

PMID:15578982

Abstract

Nef is a viral pathogenicity factor that has an important role in disease progression associated with HIV infection. Yet, no antiviral drugs capable of inhibiting of Nef are available or in clinical trials today. In this review the challenges and potential involved in pharmaceutical targeting of Nef are discussed in light of current understanding of the molecular mechanisms of Nef action, with a special emphasis on effector functions of Nef that are mediated via SH3 domain-directed interactions with host cell proteins.

摘要

Nef是一种病毒致病因子，在与HIV感染相关的疾病进展中起重要作用。然而，目前尚无能够抑制Nef的抗病毒药物可供使用或处于临床试验阶段。在这篇综述中，根据目前对Nef作用分子机制的理解，讨论了以Nef为药物靶点所面临的挑战和潜在可能性，特别强调了通过与宿主细胞蛋白的SH3结构域定向相互作用介导的Nef效应功能。