Liu Q, Xie F, Siedlak S L, Nunomura A, Honda K, Moreira P I, Zhua X, Smith M A, Perry G
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA.
Cell Mol Life Sci. 2004 Dec;61(24):3057-75. doi: 10.1007/s00018-004-4268-8.
The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic mice, these studies provided new insights into neurofilament function. The function of each subunit, the relationship of neurofilaments with other cytoskeletal elements and their clinical significance are topics of increasing attention.
神经丝是大型有髓神经元的主要组成部分,尽管它们在100多年前就被发现,但对其功能仍知之甚少。最近的研究表明,神经丝与许多神经退行性疾病密切相关,如肌萎缩侧索硬化症、帕金森病、阿尔茨海默病和糖尿病。通过体外试验、培养和转基因小鼠,这些研究为神经丝功能提供了新的见解。每个亚基的功能、神经丝与其他细胞骨架成分的关系及其临床意义是越来越受关注的话题。