Jiao Hua-bo, Qiao Zhi, Tan Xiang-long, Du Jun-dong, Fei Yang, Wang Da-dong, Li Ji-ye, Yao Yong-ming
304th Division, General Hospital of PLA, Beijing 100037, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Dec;16(12):712-4.
To evaluate the effects of anticoagulation therapy with low molecular weight heparin in acute pancreatitis.
Low molecular weight heparin, in a dose of 40 mg or 0.01 ml/kg, by subcutaneous injection, every 12 hours, was administered to 17 acute pancreatitis patients combined with conventional therapy. The changes of serum enzymology and prognosis in patients treated with low molecular weight heparin or conventional therapy were observed.
Anticoagulation by low molecular weight heparin could significantly decrease the blood white cell count of patients with acute pancreatitis and increase their arterial blood oxygen partial pressure. It could cut down the duration of hospitalization and reduce the aggravation rate, secondary operation rate, and mortality of these patients without increasing hemorrhagic tendency or its related complications.
Anticoagulation therapy with low molecular weight heparin is safe and effective in the treatment of acute pancreatitis, and it may improve its prognosis.
评估低分子量肝素抗凝治疗在急性胰腺炎中的效果。
17例急性胰腺炎患者在接受常规治疗的同时，皮下注射低分子量肝素，剂量为40mg或0.01ml/kg，每12小时一次。观察低分子量肝素治疗组与常规治疗组患者血清酶学变化及预后情况。
低分子量肝素抗凝可显著降低急性胰腺炎患者的白细胞计数，提高动脉血氧分压。可缩短住院时间，降低病情加重率、二次手术率及死亡率，且不增加出血倾向或其相关并发症。
低分子量肝素抗凝治疗急性胰腺炎安全有效，可能改善其预后。
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