一名男性患者在接受包括全身照射和骨髓移植在内的急性淋巴细胞白血病治疗后发生乳腺癌。
Breast cancer in a male patient after treatment of acute lymphoblastic leukemia including total body irradiation and bone marrow transplantation.
作者信息
Latz D, Alfrink M, Nassar N, Beyerle C
机构信息
Abteilung Strahlentherapie, Radiologische Gemeinschaftspraxis am Klinikum Coburg, Germany.
出版信息
Onkologie. 2004 Oct;27(5):477-9. doi: 10.1159/000080369.
BACKGROUND
With increasing numbers of patients subjected to total body irradiation and bone marrow transplantation for treatment of several systemic malignancies more and more patients with second malignancies were observed.
CASE REPORT
We report the case of a 29- year-old man who developed breast cancer 13 years after treatment for acute lymphoblastic leukemia. Therapy for leukemia included total body irradiation (TBI) and bone marrow transplantation (BMT). Breast cancer was treated with mastectomy and irradiation of the left chest wall. 17 months later the patient developed malignant pleural effusion and died despite chemotherapy and hormonal therapy due to further tumor progression.
CONCLUSION
The increased risk for secondary solid cancers after TBI and BMT and the greater risk among younger patients indicate the need for lifelong careful follow up.
背景
随着越来越多的患者接受全身照射和骨髓移植以治疗多种系统性恶性肿瘤，观察到的继发第二原发性恶性肿瘤的患者越来越多。
病例报告
我们报告一例29岁男性患者，其在急性淋巴细胞白血病治疗13年后发生乳腺癌。白血病治疗包括全身照射（TBI）和骨髓移植（BMT）。乳腺癌采用乳房切除术和左胸壁照射治疗。17个月后，患者出现恶性胸腔积液，尽管进行了化疗和激素治疗，但由于肿瘤进一步进展仍死亡。
结论
全身照射和骨髓移植后继发实体癌的风险增加，且年轻患者风险更高，这表明需要进行终身密切随访。
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