A case of multiple sclerosis with homonymous hemianopia examined by positron emission tomography.

作者信息

Murai Hideki, Kiyosawa Motohiro, Suzuki Yukihisa, Mizoguchi Shoichi, Ishii Kenji, Ishikawa Kinya, Akashi Takumi

机构信息

Department of Ophthalmology and Visual Science, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8591, Japan.

出版信息

Jpn J Ophthalmol. 2004 Nov-Dec;48(6):591-3. doi: 10.1007/s10384-004-0128-1.

DOI:10.1007/s10384-004-0128-1

PMID:15592787

Abstract

BACKGROUND

To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia.

CASE

A 20-year-old man visited us with a complaint of left homonymous hemianopia and headache.

OBSERVATIONS

The patient's visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by PET with (18)F-fluorodeoxy glucose. PET with (11)C-flumazenyl revealed a reduction of (11)C-uptake in the demyelinated optic radiation, and only a slight reduction of (11)C-uptake in the primary visual cortex. The results of (11)C-flumazenyl PET suggested a slight reduction of neuronal density. In 2 years, the visual field recovered to the normal state.