Watts Paul
University of Hull, Department of Chemistry, Hull, UK.
Curr Opin Drug Discov Devel. 2004 Nov;7(6):807-12.
This article reviews the use of microreactors in the field of organic and combinatorial synthesis with regard to drug discovery applications. Research conducted into microreactors that enable in situ purification is described, and it is proposed that compounds could potentially be screened within an integrated bioassay system. A description of how it would be possible to use this technology to prepare larger quantities of pharmaceutical intermediates is also given.
本文综述了微反应器在有机合成和组合合成领域中在药物发现应用方面的使用情况。描述了对能够进行原位纯化的微反应器的研究,并提出化合物有可能在集成生物测定系统内进行筛选。还介绍了如何利用该技术制备大量药物中间体。