多囊卵巢综合征：一种导致下丘脑-垂体-肾上腺轴功能失调的卵巢疾病？
PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis?
作者信息
Doi Suhail A R, Towers Philip A, Scott Christopher J, Al-Shoumer Kamal A S
机构信息
Division of Endocrinology, Mubarak Al Kabeer Hospital and Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 64849, Shuwaikh 70459, Kuwait.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2005 Jan 10;118(1):4-16. doi: 10.1016/j.ejogrb.2004.06.024.
This review focuses on the role of the ovaries in the pathogenesis of the polycystic ovarian syndrome. In particular, the failure of follicular development, hypothalamo-pituitary dysregulation, alterations in adrenal steroid output and derangement of intermediary metabolism are discussed in the context of the ovaries. It is concluded that the central and adrenal alterations associated with PCOS are unlikely to be primary but rather are secondary to the events within the ovary.
本综述聚焦于卵巢在多囊卵巢综合征发病机制中的作用。特别在卵巢的背景下，讨论了卵泡发育障碍、下丘脑 - 垂体调节异常、肾上腺类固醇分泌改变及中间代谢紊乱。得出的结论是，与多囊卵巢综合征相关的中枢和肾上腺改变不太可能是原发性的，而更可能是卵巢内事件的继发性结果。
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