Alcón Elmer P Q, Lopes Ricardo T, de Almeida Carlos E V
Laboratório de Ciências Radiológicas, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Appl Radiat Isot. 2005 Feb;62(2):301-6. doi: 10.1016/j.apradiso.2004.08.035.
Nowadays, more than one million percutaneous transluminal coronary angioplasties are being performed annually throughout the world. Restenosis is a significant problem associated with these angioplasty procedures. Radiation treatment with catheter-based beta-emitter sources is currently under clinical trial to prevent this problem. Due to fast and worldwide introduction of beta-sources for intravascular application, there is a growing interest in the dosimetry aspects. However, accurate dosimetry of beta-radiation is more difficult than that of gamma-radiation. Suitable detectors are not yet available with accuracy down to a tenth of a millimeter. Conventional measuring systems are not capable of such spatial resolution, except radiochromic film. However, film dosimeters have limited sensitivity and their radiation characteristics are different than those of tissue; therefore dose measurements require corrections. An alternative is to use water-equivalent plastic scintillators. In this work, organic plastic scintillator (BCF-10) dosimetry is studied using the Monte Carlo (MC) technique PENELOPE, and its radiation stability, after irradiation, is experimentally studied through electron paramagnetic resonance (EPR). Depth dose and dose profile are measured and compared to film dosimetry results. The EPR technique shows that the recovery time is dose independent in this kind of fiber and shows good stability.
如今,全世界每年进行超过一百万例经皮腔内冠状动脉成形术。再狭窄是与这些血管成形术相关的一个重大问题。目前正在进行基于导管的β发射源放射治疗以预防这一问题。由于用于血管内应用的β源迅速且在全球范围内得到推广,人们对剂量测定方面的兴趣日益浓厚。然而,β辐射的精确剂量测定比γ辐射更困难。目前还没有精度能达到十分之一毫米的合适探测器。除了放射变色胶片外,传统测量系统无法达到这样的空间分辨率。然而,胶片剂量计灵敏度有限,且其辐射特性与组织不同;因此剂量测量需要进行校正。另一种选择是使用水等效塑料闪烁体。在这项工作中,使用蒙特卡罗(MC)技术PENELOPE研究了有机塑料闪烁体(BCF - 10)的剂量测定,并通过电子顺磁共振(EPR)对其辐照后的辐射稳定性进行了实验研究。测量了深度剂量和剂量分布,并与胶片剂量测定结果进行了比较。EPR技术表明,这种纤维的恢复时间与剂量无关,且具有良好的稳定性。