Azuka Charles, Daston George P
The Procter & Gamble Company, Cincinnati, OH 45253, USA.
Birth Defects Res B Dev Reprod Toxicol. 2004 Dec;71(6):374-9. doi: 10.1002/bdrb.20026.
The developmental toxicity potential of trimethylolpropane caprylate caproate (TMPCC, CAS no. 11138-60-6) was evaluated in rats. Sprague-Dawley rats were administered TMPCC in a corn oil suspension dermally at dose levels of 0, 200, 600, or 2,000 mg/kg/day on gestation days (GD) 6-15 (sperm positive day=GD 0). Caesarean sections were performed on GD 20 and fetuses were evaluated for viability, growth, and external, visceral, and skeletal abnormalities. Each group consisted of 25 females, with at least 22 per group being pregnant. The two highest dose levels caused some local irritation at the site of application, but no decreases in maternal weight gain. There were no differences from control in any of the developmental parameters measured, including embryo/fetal viability, fetal weight, malformations, or variations. TMPCC did not cause any developmental toxicity in the Sprague-Dawley rat at dermal dosages up to 2,000 mg/kg/day.
在大鼠中评估了三羟甲基丙烷辛酸己酸酯（TMPCC，化学物质登记号：11138 - 60 - 6）的发育毒性潜力。在妊娠第6至15天（精子阳性日 = 妊娠第0天），将TMPCC以玉米油悬浮液的形式经皮给予斯普拉格 - 道利大鼠，剂量水平分别为0、200、600或2000 mg/kg/天。在妊娠第20天进行剖腹产，并对胎儿的活力、生长以及外部、内脏和骨骼异常进行评估。每组由25只雌性大鼠组成，每组至少22只怀孕。两个最高剂量水平在给药部位引起了一些局部刺激，但母体体重增加没有减少。在所测量的任何发育参数中，包括胚胎/胎儿活力、胎儿体重、畸形或变异，与对照组均无差异。在高达2000 mg/kg/天的经皮给药剂量下，TMPCC在斯普拉格 - 道利大鼠中未引起任何发育毒性。
