Amphetamine-induced increase in planarian locomotor activity and block by UV light.
作者信息
Raffa Robert B, Martley Andrea F
机构信息
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA.
出版信息
Brain Res. 2005 Jan 7;1031(1):138-40. doi: 10.1016/j.brainres.2004.10.051.
Abstract
The dopamine D2-receptor antagonist sulpiride decreases spontaneous locomotor velocity of planarians (pLMV) in an enantiomeric-selective and dose-dependent manner and is significantly attenuated by UV light (254 and 366 nm). We now report that amphetamine (10 microM) produced the opposite effect and was also reversed by UV light. These findings strengthen the hypothesis that the effects of dopaminergic ligands and UV light on pLMV relate to interaction with neurotransmitter transduction process(es).
摘要
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