测量视锥细胞对视网膜电图b波的贡献以评估RCS大鼠的功能并预测解剖学挽救情况。

Measuring the cone contribution to the ERG b-wave to assess function and predict anatomical rescue in RCS rats.

作者信息

Pinilla I, Lund R D, Lu B, Sauvé Y

机构信息

Moran Eye Center, Ophthalmology and Visual Sciences, University of Utah, 75 North Medical Drive, Salt Lake City, UT 84132, USA.

出版信息

Vision Res. 2005 Mar;45(5):635-41. doi: 10.1016/j.visres.2004.09.014.

DOI:10.1016/j.visres.2004.09.014

PMID:15621180

Abstract

Subretinal injections of human retinal pigment epithelial (RPE) cells early in the course of retinal degeneration in Royal College of Surgeons (RCS) rats can rescue photoreceptors. Fourteen injected animals were studied using a double flash electroretinogram (ERG): 10 were examined longitudinally and four terminally with immunohistochemistry. The proportion of cone contribution to the ERG b-wave rather than the absolute size of isolated cone response proved to be a reliable indicator of function over time and a predictor of the proportion of cones identified anatomically in the area of optimal photoreceptor rescue.

摘要

在皇家外科学院（RCS）大鼠视网膜变性病程早期进行视网膜下注射人视网膜色素上皮（RPE）细胞可挽救光感受器。使用双闪光视网膜电图（ERG）对14只注射动物进行了研究：10只进行纵向检查，4只进行终末免疫组织化学检查。结果证明，ERG b波中视锥细胞贡献的比例而非孤立视锥细胞反应的绝对大小是随时间变化的功能可靠指标，也是在最佳光感受器挽救区域解剖学上鉴定出的视锥细胞比例的预测指标。