一些含有O,O-正丁基和O,O-正戊基-乙二胺-N,N'-二-3-丙酸酯以及卤代配体的铂（II/IV）配合物对HeLa和K562细胞系及人外周血单个核细胞的活性。
Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N'-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC.
作者信息
Kaluderović Goran N, Dinović Vesna M, Juranić Zorica D, Stanojković Tatjana P, Sabo Tibor J
机构信息
Faculty of Chemistry, University of Belgrade, P.O. Box 158, 11001 Belgrade, Serbia and Montenegro.
出版信息
J Inorg Biochem. 2005 Feb;99(2):488-96. doi: 10.1016/j.jinorgbio.2004.10.025.
This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [II], dichlorodiiodo(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [III], and dichloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(II) [V] complexes, with the formulae [Pt(dbeddp)Br(3)Cl], [Pt(dbeddp)Cl(2)I(2)] and [Pt(dbeddp)Cl(2)], respectively. The complexes were characterized by elemental analysis, infrared, (1)H and (13)C NMR spectroscopy and electrospray mass spectrometry. In the aim to assess the selectivity in the antitumor action of these complexes, as well, as tetrachloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [I] and tetrachloro(O,O-n-pentyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [IV], the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells, to human myelogenous leukemia K562 cells and to normal immunocompetent cells, i.e., on human peripheral blood mononuclear PBMC cells.
本文报道了氯三溴（O，O-正丁基-乙二胺-N，N'-二-3-丙酸酯）铂（IV）[II]、二氯二碘（O，O-正丁基-乙二胺-N，N'-二-3-丙酸酯）铂（IV）[III]和二氯（O，O-正丁基-乙二胺-N，N'-二-3-丙酸酯）铂（II）[V]配合物的合成与表征，其化学式分别为[Pt（dbeddp）Br₃Cl]、[Pt（dbeddp）Cl₂I₂]和[Pt（dbeddp）Cl₂]。通过元素分析、红外光谱、¹H和¹³C核磁共振光谱以及电喷雾质谱对这些配合物进行了表征。为了评估这些配合物以及四氯（O，O-正丁基-乙二胺-N，N'-二-3-丙酸酯）铂（IV）[I]和四氯（O，O-正戊基-乙二胺-N，N'-二-3-丙酸酯）铂（IV）[IV]在抗肿瘤作用中的选择性，测定了这些化合物对人腺癌HeLa细胞、人骨髓性白血病K562细胞以及正常免疫活性细胞，即人外周血单个核PBMC细胞的抗增殖作用。
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