用卡泊芬净治疗对氟康唑耐药的热带念珠菌性心内膜炎

[Treatment with caspofungin of Candida tropicalis endocarditis resistant to fluconazol].

作者信息

del Castillo Marcelo, Wainsztein Nestor, Klein Francisco, Manganello Silvana, Orellana Nora

机构信息

FLENI (Instituto de Investigaciones Neurológicas Raúl Carrea), Buenos Aires, Argentina.

出版信息

Medicina (B Aires). 2004;64(2):152-4.

PMID:15628305

Abstract

Fungal endocarditis, in particular due to Candida species, requires medical and surgical treatment and amphotericin B is the drug of choice. Caspofungin is an echinocandin very effective against Candida and Aspergillus. We present a patient with Candida tropicalis endocarditis, fluconazol resistant, treated with caspofungin, on a compassional basis as a result of adverse effects with amphotericin B. The patient had a microbiological response.

摘要

真菌性心内膜炎，尤其是由念珠菌属引起的，需要药物和手术治疗，两性霉素B是首选药物。卡泊芬净是一种棘白菌素，对念珠菌和曲霉菌非常有效。我们报告一例热带念珠菌性心内膜炎患者，该患者对氟康唑耐药，因两性霉素B的不良反应，在同情用药的基础上接受了卡泊芬净治疗。该患者有微生物学反应。