Gilger J W, Pennington B F, DeFries J C
University of Denver, Department of Psychology, CO 80208.
J Am Acad Child Adolesc Psychiatry. 1992 Mar;31(2):343-8. doi: 10.1097/00004583-199203000-00024.
Monozygotic and dizygotic twin pairs, in which at least one member of each pair is reading disabled (RD), were assessed for attention-deficit hyperactivity disorder (ADHD). Within pair cross-concordances of the RD and ADHD qualitative diagnoses for monozygotic twins were larger than for dizygotic twins, although not significantly so (p less than 0.10). Thus, the data suggest that RD and ADHD may be primarily genetically independent. However, trends in the data and subtype analyses suggest that in some cases RD and ADHD may occur together because of a shared genetic etiology and that a genetically mediated comorbid subtype may exist.
对同卵双胞胎和异卵双胞胎进行了评估，这些双胞胎中每对至少有一名成员存在阅读障碍（RD），评估内容为注意缺陷多动障碍（ADHD）。同卵双胞胎在RD和ADHD定性诊断方面的配对内交叉一致性高于异卵双胞胎，尽管差异不显著（p<0.10）。因此，数据表明RD和ADHD可能主要在基因上相互独立。然而，数据趋势和亚型分析表明，在某些情况下，RD和ADHD可能由于共同的遗传病因同时出现，并且可能存在一种由基因介导的共病亚型。
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