Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction.

作者信息

Kirtane Ajay J, Weisbord Aaron, Karmpaliotis Dimitrios, Murphy Sabina A, Giugliano Robert P, Cannon Christopher P, Antman Elliott M, Ohman E Magnus, Roe Matthew T, Braunwald Eugene, Gibson C Michael

机构信息

Department of Medicine, Beth Israel Deaconess Medical Center, and TIMI Study Group, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, USA.

出版信息

Am J Cardiol. 2005 Jan 15;95(2):224-7. doi: 10.1016/j.amjcard.2004.09.007.

DOI:10.1016/j.amjcard.2004.09.007

PMID:15642554

Abstract

Clinical and angiographic data were analyzed from 929 patients who had ST-elevation myocardial infarction and open epicardial arteries after fibrinolytic therapy. Residual angiographically evident thrombus was associated with more frequent Thrombolysis In Myocardial Infarction (TIMI) grade 2 flow (33.6% vs 26.8%, p = 0.03), higher corrected TIMI frame counts (34 vs 31 frames, p = 0.0003), and lower TIMI myocardial perfusion grades (43.0% vs 32.0% TIMI myocardial perfusion grades 0/1, p = 0.001) among all patients and among patients who had TIMI grade 3 flow (33.5% vs 26.0% TIMI myocardial perfusion grades 0/1, p = 0.043). In multivariate analyses, angiographically evident thrombus was associated with higher corrected TIMI frame counts and worsened myocardial perfusion independent of clinical and angiographic covariates, including TIMI grade 3 flow.

摘要