Inglis J H C
NHS Health Scotland, Woodburn House, Canaan Lane, Edinburgh.
Scott Med J. 2004 Nov;49(4):142-3. doi: 10.1177/003693300404900408.
To identify any effect on deaths and emergency admissions for poisoning resulting from the restriction on paracetamol sales introduced in September 1998.
Scotland.
Deaths from poisoning were extracted from the General Registrar (Scotland) Office annual reports for 1991 to 2001 and emergency admissions data for 1990/91 to 2001/02 was supplied by the Information and Statistics Division of NHS Scotland.
Deaths in the early 1990s, deaths from all poisonings and deaths from paracetamol poisoning were stable. After the restrictions deaths from all poisonings remained stable. Deaths from paracetamol poisoning fell by 45% in 1998 but have risen in each of the three years since to reach pre-restriction levels.
Emergency admissions in the early 1990s all poisonings rose steadily. Following the restrictions all admissions fell by 10% and paracetamol poisonings fell by 14%. All admissions remained lower for a further two years but are now rising again. Paracetamol poisonings remained lower for a second year but the last two years have both seen 10% increases to reach record levels.
The restrictions caused a dramatic 45% fall in deaths from paracetamol poisoning and reversed a relentless upward rise in all admissions for poisoning. The benefits were short-lived lasting about two years. Deaths and admissions are rising again and admissions are at record levels.
Restricting paracetamol sales resulted in significant health gain. Further restrictions and public education on this valuable but dangerous drug are both urgently needed.
确定1998年9月对扑热息痛销售实施限制后,对中毒死亡及急诊入院情况的影响。
苏格兰。
中毒死亡数据取自1991年至2001年苏格兰总登记官办公室的年度报告,1990/91至2001/02年的急诊入院数据由苏格兰国民保健服务信息与统计司提供。
20世纪90年代初,所有中毒死亡及扑热息痛中毒死亡情况稳定。实施限制措施后,所有中毒死亡情况保持稳定。1998年扑热息痛中毒死亡人数下降了45%,但在随后的三年中每年都有所上升,达到了限制实施前的水平。
20世纪90年代初,所有中毒急诊入院人数稳步上升。实施限制措施后,所有入院人数下降了10%,扑热息痛中毒入院人数下降了14%。在接下来的两年里,所有入院人数持续较低,但现在又开始上升。扑热息痛中毒入院人数连续第二年保持较低水平,但在过去两年中均增长了10%,达到创纪录水平。
这些限制措施使扑热息痛中毒死亡人数大幅下降了45%,扭转了中毒急诊入院人数持续上升的趋势。这些益处是短暂的,持续了大约两年。死亡人数和入院人数又在上升,入院人数达到创纪录水平。
限制扑热息痛销售带来了显著的健康收益。迫切需要对这种有价值但危险的药物进一步实施限制措施并开展公众教育。