Zini L, Yiou R, Lecoeur C, Biserte J, Abbou C, Chopin D K
Service d'urologie, hôpital Claude Huriez, CHRU de Lille, 59037 Lille cedex, France.
Ann Urol (Paris). 2004 Dec;38(6):266-74. doi: 10.1016/j.anuro.2004.09.001.
Tissue engineering refers to the techniques that are aimed at regeneration of human tissues and organs. Two elements are necessary for these techniques: matrix and cells. Matrix is the scaffold where tissues may organise. Cells are either autologous cells stimulated to regenerate in vivo, aided by implantation of matrix ("guided tissue regeneration"), or autologous cells cultured outside the body (in vitro) and later returned as auto-transplants. All types of conventional tissue reconstructive surgery need tissue engineering. These techniques have been introduced recently into the clinical practice. One of the main limitations of reconstructive surgery in genitourinary tract is the lack of autologous tissue. Two autotransplants could be distinguished: coherent tissue structure or cell suspensions. The great number of studies published in this area emphasizes the importance of the future clinical implication in urology.
组织工程是指旨在实现人体组织和器官再生的技术。这些技术需要两个要素:基质和细胞。基质是组织可以在其上组织形成的支架。细胞既可以是在体内通过植入基质(“引导组织再生”)辅助刺激再生的自体细胞,也可以是在体外培养(体外)然后作为自体移植返回的自体细胞。所有类型的传统组织重建手术都需要组织工程。这些技术最近已被引入临床实践。泌尿生殖道重建手术的主要限制之一是缺乏自体组织。可以区分两种自体移植:连贯的组织结构或细胞悬液。该领域发表的大量研究强调了其在泌尿外科未来临床应用中的重要性。