Reynolds Lindsay M, Cochran Susan M, Morris Brian J, Pratt Judith A, Reynolds Gavin P
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
Schizophr Res. 2005 Mar 1;73(2-3):147-52. doi: 10.1016/j.schres.2004.02.003.
Administration of phencyclidine (PCP) to both humans and animals models the symptoms of schizophrenia. Brain concentrations of N-acetylaspartate (NAA) are reduced in this disease, reflecting neuronal dysfunction. This study investigates the effects in rats of a chronic intermittent regime of PCP on NAA and its precursor N-acetylaspartylglutamate (NAAG) in rat frontal and temporal cortex, hippocampus and striatum, determined by HPLC. We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia.
给人类和动物施用苯环己哌啶（PCP）会模拟精神分裂症的症状。在这种疾病中，大脑中N-乙酰天门冬氨酸（NAA）的浓度会降低，这反映了神经元功能障碍。本研究通过高效液相色谱法（HPLC）研究了大鼠慢性间歇性PCP给药方案对大鼠额叶、颞叶皮质、海马体和纹状体中NAA及其前体N-乙酰天门冬氨酰谷氨酸（NAAG）的影响。我们发现，只有在颞叶皮质中，PCP会显著导致NAA和NAAG缺乏；海马体中的NAAG显著升高。这些变化与精神分裂症的尸检结果密切相关。
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