闭塞性细支气管炎综合征患者诱导痰的变化及其与单肺和双肺移植受者肺功能测定的相关性

Changes in induced sputum in the presence of bronchiolitis obliterans syndrome and correlation with spirometry in single and bilateral lung transplant recipients.

作者信息

Allen David J, Fildes James E, Yonan Nizar, Leonard Colm T

机构信息

North West Lung Research Centre, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, UK M23 9LT.

出版信息

J Heart Lung Transplant. 2005 Jan;24(1):88-91. doi: 10.1016/j.healun.2003.10.003.

DOI:10.1016/j.healun.2003.10.003

PMID:15653385

Abstract

Bronchiolitis obliterans syndrome is a clinical diagnosis based on lung function parameters. Using induced sputum, taken from lung transplant recipients, this paper reports on the correlation between the neutrophil count and the percentage change from postoperative baseline for FEV(1), FEF(50), and FEF(25-75). In double lung transplant recipients the correlations were significant for FEV(1) (r = -0.68, p = 0.002), FEF(50) (r = -0.65, p = 0.016), and FEF(25-75) (r = -0.56, p = 0.016). In single lung transplant recipients, no significant correlations were seen.

摘要

闭塞性细支气管炎综合征是一种基于肺功能参数的临床诊断。本文利用从肺移植受者获取的诱导痰，报告了中性粒细胞计数与术后基线相比FEV(1)、FEF(50)和FEF(25 - 75)的百分比变化之间的相关性。在双肺移植受者中，FEV(1)（r = -0.68，p = 0.002）、FEF(50)（r = -0.65，p = 0.016）和FEF(25 - 75)（r = -0.56，p = 0.016）的相关性显著。在单肺移植受者中，未观察到显著相关性。