催乳素和皮质醇对人自然杀伤细胞（NK）表面表达及自然细胞毒性受体（NKp46、NKp44和NKp30）功能的影响。
Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30).
作者信息
Mavoungou E, Bouyou-Akotet M K, Kremsner P G
机构信息
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon.
出版信息
Clin Exp Immunol. 2005 Feb;139(2):287-96. doi: 10.1111/j.1365-2249.2004.02686.x.
Abstract
The surface density of the triggering receptors (e.g. NKp46 and NKp30) responsible for natural killer (NK) cell-mediated cytotoxicity determines the ability of NK cells to kill susceptible target cells. In this study, we show that prolactin up-regulates and cortisol down-regulates the surface expression of NKp46 and NKp30. The prolactin-mediated activation and the cortisol-mediated inhibition of natural cytotoxicity receptor (NCR) surface expression reflects gene regulation at the transcriptional level. NKp46 and NKp30 are the major receptors involved in the NK-mediated killing of K562, a human chronic myelogenous leukaemia cell line. Accordingly, the prolactin dramatically increased the NK-mediated killing of the K562 cell line, whereas cortisol abolished this activity. Our data suggest a mechanism by which prolactin activates the lytic function of NK cells, and cortisol inhibits the NK-mediated attack.
摘要
负责自然杀伤（NK）细胞介导的细胞毒性的触发受体（如NKp46和NKp30）的表面密度决定了NK细胞杀伤易感靶细胞的能力。在本研究中，我们发现催乳素上调而皮质醇下调NKp46和NKp30的表面表达。催乳素介导的自然细胞毒性受体（NCR）表面表达的激活和皮质醇介导的抑制反映了转录水平的基因调控。NKp46和NKp30是参与NK介导的对人慢性髓性白血病细胞系K562杀伤的主要受体。因此，催乳素显著增加了NK介导的对K562细胞系的杀伤，而皮质醇则消除了这种活性。我们的数据提示了一种机制，通过该机制催乳素激活NK细胞的裂解功能，而皮质醇抑制NK介导的攻击。
相似文献
1
Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30).
Clin Exp Immunol. 2005 Feb;139(2):287-96. doi: 10.1111/j.1365-2249.2004.02686.x.
2
The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44).
Eur J Immunol. 2003 Sep;33(9):2410-8. doi: 10.1002/eji.200324141.
3
Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C.
Gut. 2006 Jun;55(6):869-77. doi: 10.1136/gut.2005.076463. Epub 2005 Dec 1.
4
Expression of natural cytotoxicity receptors NKp30, NKp44, and NKp46 mRNAs and proteins by human hematopoietic and non-hematopoietic cells.
Leuk Res. 2006 Jan;30(1):37-46. doi: 10.1016/j.leukres.2005.06.020. Epub 2005 Aug 2.
5
CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity.
Eur J Immunol. 2003 Dec;33(12):3367-76. doi: 10.1002/eji.200324425.
6
NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen species.
Br J Haematol. 2006 Jan;132(1):91-8. doi: 10.1111/j.1365-2141.2005.05842.x.
7
NKp30-dependent cytolysis of filovirus-infected human dendritic cells.
Cell Microbiol. 2007 Apr;9(4):962-76. doi: 10.1111/j.1462-5822.2006.00844.x.
8
Identification of the amino acid sequence motif for conventional PKC-mediated regulation of NKp46 surface expression.
Scand J Immunol. 2010 Jun;71(6):413-9. doi: 10.1111/j.1365-3083.2010.02395.x.
9
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Annu Rev Immunol. 2001;19:197-223. doi: 10.1146/annurev.immunol.19.1.197.
10
Selective cross-talk among natural cytotoxicity receptors in human natural killer cells.
Eur J Immunol. 2003 May;33(5):1235-41. doi: 10.1002/eji.200323896.
引用本文的文献
1
Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk.
Cancers (Basel). 2024 Nov 1;16(21):3706. doi: 10.3390/cancers16213706.
2
A systematic review and meta-analysis of cortisol levels in Plasmodium infections.
Sci Rep. 2024 Aug 6;14(1):18162. doi: 10.1038/s41598-024-68596-0.
3
Hepatic transcript profiling in beef cattle: Effects of feeding endophyte-infected tall fescue seeds.
PLoS One. 2024 Jul 26;19(7):e0306431. doi: 10.1371/journal.pone.0306431. eCollection 2024.
4
Adrenal insufficiency in liver diseases - pathophysiology and underlying mechanisms.
Rev Endocr Metab Disord. 2024 Aug;25(4):663-676. doi: 10.1007/s11154-024-09874-0. Epub 2024 Feb 2.
5
Effect of prolactin on cytotoxicity and oxidative stress in ovine ovarian granulosa cells.
PeerJ. 2023 Jul 10;11:e15629. doi: 10.7717/peerj.15629. eCollection 2023.
6
Anesthesia and cancer recurrence: an overview.
J Anesth Analg Crit Care. 2022 Jul 20;2(1):33. doi: 10.1186/s44158-022-00060-9.
7
Relationship between Serum Cortisol, Dehydroepiandrosterone Sulfate (DHEAS) Levels, and Natural Killer Cell Activity: A Cross-Sectional Study.
J Clin Med. 2023 Jun 13;12(12):4027. doi: 10.3390/jcm12124027.
8
Cytotoxic CD8 T cells may be drivers of tissue destruction in Sjögren's syndrome.
Sci Rep. 2022 Sep 14;12(1):15427. doi: 10.1038/s41598-022-19397-w.
9
Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Implications for Female Reproductive Health.
Front Endocrinol (Lausanne). 2022 Jun 27;13:904744. doi: 10.3389/fendo.2022.904744. eCollection 2022.
10
Differential modulation of natural killer cell cytotoxicity by 17β-estradiol and prolactin through the NKG2D/NKG2DL axis in cervical cancer cells.
Oncol Lett. 2022 Jun 28;24(2):288. doi: 10.3892/ol.2022.13408. eCollection 2022 Aug.
本文引用的文献
1
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.
Eur J Immunol. 2004 Apr;34(4):961-71. doi: 10.1002/eji.200324705.
2
Expression of prolactin receptor and response to prolactin stimulation of human NK cell lines.
Cell Res. 2004 Feb;14(1):67-73. doi: 10.1038/sj.cr.7290204.
3
Depressed natural killer cell cytotoxicity against Plasmodium falciparum-infected erythrocytes during first pregnancies.
Clin Infect Dis. 2004 Feb 1;38(3):342-7. doi: 10.1086/380646. Epub 2004 Jan 13.
4
Unravelling natural killer cell function: triggering and inhibitory human NK receptors.
EMBO J. 2004 Jan 28;23(2):255-9. doi: 10.1038/sj.emboj.7600019. Epub 2003 Dec 18.
5
Natural killer (NK) cell-mediated cytolysis of Plasmodium falciparum-infected human red blood cells in vitro.
Eur Cytokine Netw. 2003 Jul-Sep;14(3):134-42.
6
Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum.
Ann N Y Acad Sci. 2003 Nov;997:136-49. doi: 10.1196/annals.1290.016.
7
Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.
J Immunol. 2003 Nov 15;171(10):5396-405. doi: 10.4049/jimmunol.171.10.5396.
8
The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.
Blood. 2004 Jan 15;103(2):664-72. doi: 10.1182/blood-2003-05-1716. Epub 2003 Sep 22.
9
The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44).
Eur J Immunol. 2003 Sep;33(9):2410-8. doi: 10.1002/eji.200324141.
10
Prolactin and autoimmunity.
Autoimmun Rev. 2002 Dec;1(6):360-4. doi: 10.1016/s1568-9972(02)00081-2.
Zotero 插件