Mauro E, Fraulini C, Rigolin G M, Galeotti R, Spanedda R, Castoldi G
Section of Hematology, Department of Biomedical Sciences, University of Ferrara, Ferrara, Italy.
Eur J Haematol. 2005 Feb;74(2):172-4. doi: 10.1111/j.1600-0609.2004.00358.x.
Tumor necrosis factor alpha (TNF-alpha) seems to play a key role in the pathogenesis of Langerhans' cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF-alpha. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.
肿瘤坏死因子α（TNF-α）似乎在朗格汉斯细胞组织细胞增多症（LCH）的发病机制中起关键作用。沙利度胺是一种包括TNF-α在内的炎性细胞因子的免疫调节剂。据我们所知，这是首例用沙利度胺成功治疗的播散性LCH病例。
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