Baldwin L, Lee A H S, Al-Talib R K, Theaker J M
Department of Cellular Pathology, Southampton University Hospitals NHS Trust, Southampton, UK.
Histopathology. 2005 Jan;46(1):50-6. doi: 10.1111/j.1365-2559.2005.02051.x.
To describe a series of 10 cases of transitional cell carcinoma which show morphological features which mimic lobular carcinoma of the breast and diffuse carcinoma of the stomach.
Ten cases were identified from the files at Southampton University Hospitals NHS Trust and from the authors' consultation files. Immunostains were performed and clinical information was obtained. Eight of the patients were male and two female. Ages ranged from 52 to 77 years at presentation. All of the tumours showed areas where the tumour was composed of uniform cells with a discohesive single-cell, diffusely invasive growth pattern. In areas the tumour cells were arranged in linear single-cell files and in separate areas solid sheets of discohesive cells. In all of the cases some tumour cells showed prominent intracytoplasmic vacuoles. In addition to this pattern, four cases showed typical transitional cell carcinoma or carcinoma in situ. The majority of the tumours expressed cytokeratin 20 but not oestrogen receptors.
This study highlights a pattern of diffusely invasive transitional cell carcinoma not previously described and one which is important to recognize in order to avoid misdiagnosis of metastatic lobular carcinoma of the breast, especially in small biopsies.
描述一系列10例具有模仿乳腺小叶癌和胃弥漫性癌形态特征的移行细胞癌。
从南安普敦大学医院国民保健服务信托基金的档案以及作者的会诊档案中识别出10例病例。进行了免疫染色并获取了临床信息。8例患者为男性,2例为女性。就诊时年龄在52至77岁之间。所有肿瘤均显示出肿瘤由形态一致的细胞组成的区域,具有离散的单细胞、弥漫性浸润性生长模式。在某些区域,肿瘤细胞呈线性单细胞排列,在其他区域则为离散细胞的实性片层。所有病例中,部分肿瘤细胞显示出明显的胞质内空泡。除了这种模式外,4例显示典型的移行细胞癌或原位癌。大多数肿瘤表达细胞角蛋白20,但不表达雌激素受体。
本研究突出了一种此前未描述过的弥漫性浸润性移行细胞癌模式,这种模式对于避免误诊为乳腺转移性小叶癌很重要,尤其是在小活检中。