小鼠睾丸特异性基因位置聚类的全基因组规模分析。
Genome-scale analysis of positional clustering of mouse testis-specific genes.
作者信息
Li Quan, Lee Bernett T K, Zhang Louxin
机构信息
Institute for Infocomm Research, Heng Mui Keng Terrace 21, Singapore.
出版信息
BMC Genomics. 2005 Jan 19;6:7. doi: 10.1186/1471-2164-6-7.
BACKGROUND
Genes are not randomly distributed on a chromosome as they were thought even after removal of tandem repeats. The positional clustering of co-expressed genes is known in prokaryotes and recently reported in several eukaryotic organisms such as Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens. In order to further investigate the mode of tissue-specific gene clustering in higher eukaryotes, we have performed a genome-scale analysis of positional clustering of the mouse testis-specific genes.
RESULTS
Our computational analysis shows that a large proportion of testis-specific genes are clustered in groups of 2 to 5 genes in the mouse genome. The number of clusters is much higher than expected by chance even after removal of tandem repeats.
CONCLUSION
Our result suggests that testis-specific genes tend to cluster on the mouse chromosomes. This provides another piece of evidence for the hypothesis that clusters of tissue-specific genes do exist.
背景
基因并非如人们所想的那样在去除串联重复序列后仍随机分布在染色体上。共表达基因的位置聚类在原核生物中是已知的，并且最近在几种真核生物中也有报道，如秀丽隐杆线虫、黑腹果蝇和人类。为了进一步研究高等真核生物中组织特异性基因聚类的模式，我们对小鼠睾丸特异性基因的位置聚类进行了全基因组规模分析。
结果
我们的计算分析表明，在小鼠基因组中，很大一部分睾丸特异性基因以2至5个基因的组进行聚类。即使去除串联重复序列后，聚类的数量仍远高于随机预期。
结论
我们的结果表明，睾丸特异性基因倾向于在小鼠染色体上聚类。这为组织特异性基因簇确实存在这一假说提供了又一证据。
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