从门控心肌灌注单光子发射计算机断层扫描成像获得的左心室功能参数：两种数据处理系统的比较

Left ventricular function parameters obtained from gated myocardial perfusion SPECT imaging: a comparison of two data processing systems.

作者信息

Tout Deborah A, Rogers Angela, Van Aswegen Andries, Underwood Stephen R

机构信息

Imperial College London, National Heart and Lung Institute, Royal Brompton Campus, London, UK.

出版信息

Nucl Med Commun. 2005 Feb;26(2):103-7. doi: 10.1097/00006231-200502000-00004.

DOI:10.1097/00006231-200502000-00004

PMID:15657501

Abstract

BACKGROUND AND AIM

The Cedars-Sinai Quantitative Gated Single Photon Emission Computed Tomography (SPECT) (QGS) program, used to quantify left ventricular function parameters from gated myocardial perfusion scintigraphy (MPS), has been extensively validated and compared with other methods of quantification. However, little is known about the reproducibility of QGS on different processing systems. This study compared the findings of QGS running on workstations provided by two different manufacturers.

METHODS

Gated rest MPS studies of 50 patients were analysed retrospectively. Filtered back-projection (FBP) was performed using identical parameters on Philips Pegasys and Nuclear Diagnostics Hermes workstations to produce gated short-axis (SA) slices. In addition, the gated SA slices reconstructed on the Pegasys were transferred to the Hermes. QGS was used to calculate the end-diastolic volume (EDV), end-systolic volume (ESV) and left ventricular ejection fraction (LVEF) in each case.

RESULTS

The mean+/-standard deviation differences between the Pegasys and Hermes function parameters were -7.06+/-3.91 ml (EDV), -5.54+/-3.21 ml (ESV) and +1.14%+/-1.43% (LVEF) when data were reconstructed on different systems, and -0.16+/-1.58 ml (EDV), -0.10+/-1.02 ml (ESV) and +0.14%+/-0.73% (LVEF) when data were reconstructed on the same system. Bland-Altman plots showed definite trends for EDV and ESV for data reconstructed on different systems, but no trends were seen for data reconstructed on the same system.

CONCLUSIONS

When data were reconstructed on two separate systems, the difference between the function parameters obtained from Pegasys and Hermes could be ascribed to differences in the reconstruction process on each system despite the use of identical parameters (filters, etc). However, when the same reconstructed data were analysed on both systems, no significant difference in left ventricular function parameters was observed.

摘要

背景与目的

雪松西奈定量门控单光子发射计算机断层扫描（SPECT）（QGS）程序用于从门控心肌灌注闪烁显像（MPS）中量化左心室功能参数，该程序已得到广泛验证，并与其他量化方法进行了比较。然而，关于QGS在不同处理系统上的可重复性知之甚少。本研究比较了在两家不同制造商提供的工作站上运行QGS的结果。

方法

回顾性分析了50例患者的门控静息MPS研究。在飞利浦Pegasys和核诊断公司的Hermes工作站上使用相同参数进行滤波反投影（FBP），以生成门控短轴（SA）切片。此外，将在Pegasys上重建的门控SA切片传输到Hermes。每种情况下均使用QGS计算舒张末期容积（EDV）、收缩末期容积（ESV）和左心室射血分数（LVEF）。

结果

当在不同系统上重建数据时，Pegasys和Hermes功能参数的平均±标准差差异分别为-7.06±3.91 ml（EDV）、-5.54±3.21 ml（ESV）和+1.14%±1.43%（LVEF）；当在同一系统上重建数据时，差异分别为-0.16±1.58 ml（EDV）、-0.10±1.02 ml（ESV）和+0.14%±0.73%（LVEF）。Bland-Altman图显示，对于在不同系统上重建的数据，EDV和ESV有明确趋势，但对于在同一系统上重建的数据则未观察到趋势。