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Single-triggered trimeric prodrugs.

作者信息

Haba Keren, Popkov Mikhail, Shamis Marina, Lerner Richard A, Barbas Carlos F, Shabat Doron

机构信息

Department of Organic Chemistry, School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

出版信息

Angew Chem Int Ed Engl. 2005 Jan 21;44(5):716-20. doi: 10.1002/anie.200461657.

DOI:10.1002/anie.200461657

PMID:15657968

Abstract

摘要

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Single-triggered trimeric prodrugs.

作者信息

Haba Keren, Popkov Mikhail, Shamis Marina, Lerner Richard A, Barbas Carlos F, Shabat Doron

机构信息

Department of Organic Chemistry, School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

出版信息

Angew Chem Int Ed Engl. 2005 Jan 21;44(5):716-20. doi: 10.1002/anie.200461657.

DOI:10.1002/anie.200461657

PMID:15657968

Abstract

摘要

相似文献

Single-triggered trimeric prodrugs.

Angew Chem Int Ed Engl. 2005 Jan 21;44(5):716-20. doi: 10.1002/anie.200461657.

Glycosidic prodrugs of highly potent bifunctional duocarmycin derivatives for selective treatment of cancer.

Angew Chem Int Ed Engl. 2010 Sep 24;49(40):7336-9. doi: 10.1002/anie.201002502.

New Taxol (paclitaxel) prodrugs designed for ADEPT and PMT strategies in cancer chemotherapy.

Bioorg Med Chem. 2006 Jul 15;14(14):5012-9. doi: 10.1016/j.bmc.2006.03.002. Epub 2006 Mar 22.

Duocarmycin-based prodrugs for cancer prodrug monotherapy.

Bioorg Med Chem. 2008 Jun 15;16(12):6312-8. doi: 10.1016/j.bmc.2008.05.009. Epub 2008 May 7.

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Bioorg Med Chem Lett. 2009 Jul 15;19(14):3725-8. doi: 10.1016/j.bmcl.2009.05.058. Epub 2009 May 18.

Design, synthesis, and antitumor activity of bile acid-polyamine-nucleoside conjugates.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):2983-6. doi: 10.1016/j.bmcl.2007.03.067. Epub 2007 Mar 25.

Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.

ChemMedChem. 2008 Dec;3(12):1946-55. doi: 10.1002/cmdc.200800250.

[Modified nucleoside phosphates as precursors of antineoplastic and antiviral compounds in a cell].

Bioorg Khim. 1996 Oct-Nov;22(10-11):777-94.

In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.

J Med Chem. 2007 May 3;50(9):2249-53. doi: 10.1021/jm0612923. Epub 2007 Apr 10.

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Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6. doi: 10.1016/j.bmcl.2008.10.029. Epub 2008 Oct 11.

引用本文的文献

Self-Immolative Domino Dendrimers as Anticancer-Drug Delivery Systems: A Review.

Pharmaceutics. 2024 May 16;16(5):668. doi: 10.3390/pharmaceutics16050668.

Incorporation of a self-immolative spacer enables mechanically triggered dual payload release.

Chem Sci. 2023 Dec 20;15(4):1472-1479. doi: 10.1039/d3sc06359c. eCollection 2024 Jan 24.

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.

Org Lett. 2021 Nov 5;23(21):8580-8584. doi: 10.1021/acs.orglett.1c03299. Epub 2021 Oct 25.

Trimethyl-Substituted Carbamate as a Versatile Self-Immolative Linker for Fluorescence Detection of Enzyme Reactions.

Molecules. 2020 May 5;25(9):2153. doi: 10.3390/molecules25092153.

A Single UV or Near IR Triggering Event Leads to Polymer Degradation into Small Molecules.

ACS Macro Lett. 2012 Jul 17;1(7):922-926. doi: 10.1021/mz3002403. Epub 2012 Jul 9.

Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide.

J Am Chem Soc. 2012 Sep 26;134(38):15758-64. doi: 10.1021/ja303372u. Epub 2012 Sep 17.

Emerging trends in metalloprotein inhibition.

Dalton Trans. 2011 Apr 14;40(14):3445-54. doi: 10.1039/c0dt01743d. Epub 2011 Feb 2.

Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide.

J Biol Inorg Chem. 2011 Feb;16(2):313-23. doi: 10.1007/s00775-010-0727-x. Epub 2010 Nov 4.

Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5584-9. doi: 10.1073/pnas.0700223104. Epub 2007 Mar 19.

Single-triggered trimeric prodrugs.

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Single-triggered trimeric prodrugs.

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