DC-SIGN及其同源物L-SIGN（DC-SIGNR）和mSIGNR1在病原体识别和免疫调节中的不同功能。

Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation.

作者信息

Koppel Estella A, van Gisbergen Klaas P J M, Geijtenbeek Teunis B H, van Kooyk Yvette

机构信息

Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, the Netherlands.

出版信息

Cell Microbiol. 2005 Feb;7(2):157-65. doi: 10.1111/j.1462-5822.2004.00480.x.

DOI:10.1111/j.1462-5822.2004.00480.x

PMID:15659060

Abstract

Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.

摘要

抗原呈递细胞表达C型凝集素，这些凝集素参与病原体捕获、加工以及抗原呈递，以诱导针对这些病原体的免疫反应。然而，越来越清楚的是，病原体已经进化出破坏某些C型凝集素功能的能力，以逃避免疫监视。一个重要的C型凝集素家族以人及小鼠中的DC-SIGN及其同源物为代表。在此，我们讨论SIGN受体的病原体结合特异性相关结构以及这些受体在小鼠和人类中的功能。