Fmr1基因敲除小鼠大脑中Rgs4信使核糖核酸表达降低。

Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse.

作者信息

Tervonen Topi, Akerman Karl, Oostra Ben A, Castrén Maija

机构信息

Neuroscience Center, University of Helsinki, P.O. Box 56, Viikinkaari 4, FIN-00014 Helsinki, Finland.

出版信息

Brain Res Mol Brain Res. 2005 Jan 5;133(1):162-5. doi: 10.1016/j.molbrainres.2004.09.023.

DOI:10.1016/j.molbrainres.2004.09.023

PMID:15661377

Abstract

In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.

摘要

在脆性X智力障碍综合征模型Fmr1基因敲除小鼠中，大脑皮层和海马CA1区G蛋白信号调节因子（Rgs）4的mRNA水平显著降低（比对照降低65%），而Rgs2的mRNA水平未降低。在缺乏相关蛋白FXR2P的动物中，Rgs4的表达正常，这表明Rgs4表达的降低是FMRP缺失所特有的，提示FMRP在G蛋白信号传导中发挥作用。