进化基因组学：检测选择需要比较数据。

Evolutionary genomics: detecting selection needs comparative data.

作者信息

Nielsen Rasmus, Hubisz Melissa J

机构信息

Centre for Bioinformatics, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark.

出版信息

Nature. 2005 Jan 20;433(7023):E6; discussion E7-8. doi: 10.1038/nature03222.

DOI:10.1038/nature03222

PMID:15662372

Abstract

Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al. describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

摘要

在分子水平上的正向选择通常通过比较数据中非同义替换与同义替换的比率（dN/dS）增加来表明。然而，普洛特金等人描述了一种基于单核苷酸序列检测正向选择的新方法。我们在此表明，该方法对有关潜在突变过程的假设特别敏感，并且不能提供一种可靠的方法来识别正向选择。