Engwerda Christian R, Beattie Lynette, Amante Fiona H
Immunology and Infection Laboratory, the Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia.
Trends Parasitol. 2005 Feb;21(2):75-80. doi: 10.1016/j.pt.2004.11.008.
There are several malaria vaccine candidates at various stages of development. Many of these target blood stages of Plasmodium falciparum. The spleen is a key site for removal of parasitized red blood cells, generation of immunity and production of new red blood cells during malaria. This article describes how all of these processes are modified following infection, and suggests that until we fully understand how these processes function and are modulated by infection, appropriate malaria vaccine design and delivery will be extremely difficult to achieve.
有几种疟疾疫苗候选物正处于不同的开发阶段。其中许多针对恶性疟原虫的血液阶段。脾脏是疟疾期间清除被寄生红细胞、产生免疫和生成新红细胞的关键部位。本文描述了感染后所有这些过程是如何被改变的，并指出在我们完全了解这些过程如何发挥作用以及如何被感染调节之前，很难实现合适的疟疾疫苗设计和接种。
