天然HIV-1 Nef蛋白可加速原代人淋巴细胞中的病毒复制。
Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes.
作者信息
de Ronde A, Klaver B, Keulen W, Smit L, Goudsmit J
机构信息
University of Amsterdam, Academic Medical Centre, Amsterdam.
出版信息
Virology. 1992 May;188(1):391-5. doi: 10.1016/0042-6822(92)90772-h.
PMID:1566581
Abstract
HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines.
摘要
从两名感染HIV-1的个体的外周血淋巴细胞DNA中直接分离出HIV-1 NEF基因，并克隆到一个HXB-2感染性分子克隆中。研究了NEF对T细胞系和原代人淋巴细胞中病毒产生的影响。天然存在的NEF可加速原代人淋巴细胞中的病毒产生，但在T细胞系中则不然。
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