可光开关的烯二炔：使用环丙烯酮作为烯二炔三键的可光裂解掩蔽基团。

Photoswitchable enediynes: use of cyclopropenone as photocleavable masking group for the enediyne triple bond.

作者信息

Poloukhtine Andrei, Popik Vladimir V

机构信息

Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA.

出版信息

Chem Commun (Camb). 2005 Feb 7(5):617-9. doi: 10.1039/b414951c. Epub 2004 Dec 10.

DOI:10.1039/b414951c

PMID:15672154

Abstract

Cyclopropenone , 2,3-benzobicyclo[8.1.0]undec-1(10)-en-4-yn-11-one, is a thermally stable compound showing no signs of decomposition after heating at 84 degrees C for 7 d, UV irradiation of which results in an efficient (Phi(300)= 0.45) and quantitative formation of benzannelated enediyne , which undergoes Bergman cyclization at the above temperature.

摘要

环丙烯酮，2,3-苯并双环[8.1.0]十一碳-1(10)-烯-4-炔-11-酮，是一种热稳定化合物，在84℃加热7天后没有分解迹象，对其进行紫外线照射会高效（Φ(300)= 0.45）且定量地生成苯并稠合烯二炔，该烯二炔在上述温度下会发生伯格曼环化反应。