Fusion polypeptides that inhibit exocytosis: fusing aptamer and cell-penetrating peptide technologies and pharmacologies.
作者信息
Eiden Lee E
机构信息
Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health Intramural Research Program, Building 36, Room 2A-11, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Mol Pharmacol. 2005 Apr;67(4):980-2. doi: 10.1124/mol.105.011429. Epub 2005 Jan 26.
PMID:15673600
Abstract
Cell-penetrating peptides are amphipathic or cationic oligopeptides able to transport covalently attached cargoes across cell membranes. Peptide aptamers are polypeptide fragments of endogenous proteins that mimic and thus perturb interactions with other cellular proteins. Combining aptamer and CPP technology can generate pharmacological reagents effective in cell culture models and in vivo.
摘要
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