Sakuraba Hirotake, Ishiguro Yoh, Yamagata Kazufumi, Tagawa Yoh-Ichi, Iwakura Yoichiro, Sekikawa Kenji, Munakata Akihiro, Nakane Akio
First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
Ann N Y Acad Sci. 2004 Dec;1029:382-4. doi: 10.1196/annals.1309.044.
Transforming growth factor (TGF)-beta has a key role in intestinal homeostasis. Our present data suggest that TGF-beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF-beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon-gamma in DSS-induced colitis.
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