Tsuji Noriko M, Nowak Bernadeta
Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan.
Ann N Y Acad Sci. 2004 Dec;1029:413-5. doi: 10.1196/annals.1309.049.
A study using gene-deficient mice revealed that IL-18 is essential for inducing antigen-specific regulatory T cells and oral tolerance. It is also suggested that IL-18 is a functional downregulator for immunogenic dendritic cells, contributing to the maintenance of homeostasis for intestinal immunity.
一项使用基因缺陷小鼠的研究表明，白细胞介素-18对于诱导抗原特异性调节性T细胞和口服耐受性至关重要。研究还表明，白细胞介素-18是免疫原性树突状细胞的功能性下调因子，有助于维持肠道免疫的稳态。
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