Wildner Gerhild, Thurau Stephan R, Diedrichs-Möhring Maria
Section of Immunobiology, Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336 Munich, Germany.
Ann N Y Acad Sci. 2004 Dec;1029:416-21. doi: 10.1196/annals.1309.050.
Gamma-delta T cells from orally tolerized rats adoptively transfer suppression of experimental autoimmune uveitis. In vivo and in vitro these regulatory cells specifically recognize retinal autoantigen peptide PDSAg and its mimotope B27PD, but not other mimicry peptides. Proliferation of gamma/delta T cells was MHC class II and CD8 dependent.
来自经口服耐受处理大鼠的γδ T细胞可通过过继转移抑制实验性自身免疫性葡萄膜炎。在体内和体外，这些调节性细胞特异性识别视网膜自身抗原肽PDSAg及其模拟表位B27PD，但不识别其他模拟肽。γ/δ T细胞的增殖依赖于MHC II类分子和CD8。
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